Emilio Ambrosio

Exploratory spatial peptidomic profiling during incubation of drug seeking following cocaine plus alcohol self-administration in young adult rats

The paper uses MALDI-IMS to identify region-specific peptide/protein alterations in rat brain regions after cocaine and cocaine-alcohol exposure, showing distinct molecular profiles.

Maternal immune activation and peripubertal stress differentially disrupt glutamatergic, endocannabinoid, and neuromodulatory signalling in the adult rat dorsal hippocampus: implications for excitatory-inhibitory balance

This study examines how maternal immune activation and peripubertal stress affect glutamatergic, endocannabinoid, and neuromodulatory signaling in the adult rat dorsal hippocampus, revealing disruptions in excitatory-inhibitory balance.

Shared and reinforcer-specific alterations in the CRH and noradrenergic systems following short- and long-term withdrawal from cocaine, heroin, and sucrose self-administration.

The paper examines stress-related biochemical changes in rats after withdrawal from cocaine, heroin, and sucrose, finding reinforcer-specific and shared adaptations in CRH and noradrenergic systems.

A hidden mark of a troubled past: neuroimaging and transcriptomic analyses reveal interactive effects of maternal immune activation and adolescent THC exposure in the absence of overt behavioural disruptions

The paper investigates the combined effects of maternal immune activation and adolescent THC exposure in rats, revealing brain and transcriptomic changes without overt behavioral disruptions.

LACK OF INTERACTIONS BETWEEN PRENATAL IMMUNE ACTIVATION AND delta9-TETRAHYDROCANNABINOL EXPOSURE DURING ADOLESCENCE IN BEHAVIOURS RELEVANT TO SYMPTOM DIMENSIONS OF SCHIZOPHRENIA IN RATS

This study examines the interaction between prenatal immune activation and adolescent THC exposure in rats, finding no synergistic effects on schizophrenia-related behaviors.

Additive, synergic and antagonistic interactions between maternal immune activation and peripubertal stress in cocaine addiction-like behaviour, morphofunctional brain parameters and striatal transcriptome.

This study investigates how maternal immune activation and peripubertal stress interact to influence cocaine addiction-like behavior and striatal transcriptome in rats.

Testing The Role Of Δ9-Tetrahydrocannabinol During Adolescence As A Gateway Drug: Behavioural, Brain Imaging And Transcriptomic Studies

This study examines the effects of adolescent THC exposure on behavior, brain structure, and gene expression in rats, finding altered psychological and brain development but no clear support for the Gateway Hypothesis.

3D SYNAPTIC ORGANIZATION OF THE RAT CA1 AND ALTERATIONS INDUCED BY COCAINE SELF-ADMINISTRATION

This study quantifies 3D synaptic organization in rat CA1 stratum radiatum under normal and cocaine self-administration conditions, finding increased synaptic size and complexity without changes in density.

Comparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administration

This study compares how cocaine, heroin, and sucrose self-administration affect perineuronal nets in different regions of the rat prefrontal cortex during early and protracted withdrawal.

Maternal immune activation in rats is associated with a lower number of dopamine receptor 3-expressing granulocytes in the male offspring with no alterations in cocaine reward, resistance to extinction or cue-induced reinstatement

The paper investigates whether maternal immune activation in rats increases vulnerability to cocaine-related behaviors in offspring, finding no differences in cocaine reward or extinction but identifying potential biomarkers for schizophrenia.

Ex vivo 1H-MRS brain metabolic profiling in a two-hit model of schizophrenia-related alterations: effects of prenatal immune activation and peripubertal stress.

This study uses ex vivo 1H-MRS to identify metabolic changes in a two-hit schizophrenia model, showing LPS and stress effects on brain metabolites.

Modulation of the mTOR pathway in male Lewis rats after morphine self-administration and subsequent extinction training

The paper examines changes in mTOR pathway gene expression and phosphoprotein levels in rat brain regions after morphine self-administration and extinction training, finding persistent amygdala-related changes.