Manuel Desco

This study shows that myosin inhibition with mavacamten is effective in treating HCM caused by both truncating and missense variants in MYBPC3, despite different pathomechanisms.

This study shows that loss of CnAβ1 enhances brown adipocyte differentiation and metabolic activity through FoxO1 activation, leading to improved insulin sensitivity and reduced body weight on a high-fat diet.

The paper introduces a new optical tissue clearing method called 'White and Clear' (WaC) that improves ease of use and clearing effectiveness across various samples.

The paper introduces an algorithm to estimate vertex-wise sulcal width maps on cortical surfaces, validated against simulations and showing correlations with age in an aging population.

ABLE extracts sulcal fundi and gyral crown lines from brain surfaces using Laplacian surface collapse, validated on HCP data to show reliable and accurate sulcal topology representation.

This study investigates how maternal immune activation and peripubertal stress interact to influence cocaine addiction-like behavior and striatal transcriptome in rats.

This study examines the effects of adolescent THC exposure on behavior, brain structure, and gene expression in rats, finding altered psychological and brain development but no clear support for the Gateway Hypothesis.