Lidia Blázquez‐Llorca

Volume Electron Microscopy of Cortical Organoids: Methods for Region Identification, Connectome Reconstruction, and Organelle Segmentation

This paper establishes a workflow for applying volume electron microscopy to human cortical organoids, enabling micro-connectomic reconstruction at nanometer resolution.

Key morphological features of human pyramidal neurons

This study quantifies morphological differences in human pyramidal neurons across cortical areas and species, revealing distinct structural features compared to mouse neurons and hippocampal neurons.

3D analysis of the synaptic organization in the Entorhinal cortex in Alzheimer's disease

The paper examines synaptic organization changes in the entorhinal cortex of Alzheimer's disease patients using 3D ultrastructural analysis and stereological methods, finding altered synaptic density and complexity.

3D SYNAPTIC ORGANIZATION OF THE RAT CA1 AND ALTERATIONS INDUCED BY COCAINE SELF-ADMINISTRATION

This study quantifies 3D synaptic organization in rat CA1 stratum radiatum under normal and cocaine self-administration conditions, finding increased synaptic size and complexity without changes in density.

3D ultrastructural study of synapses in the human entorhinal cortex

The paper performs a 3D ultrastructural analysis of synapses in the human entorhinal cortex, characterizing their morphology, density, and postsynaptic targets using FIB/SEM.

Three-dimensional synaptic organization of the human hippocampal CA1 field

This study uses 3D reconstruction of human hippocampal CA1 synapses to show most are excitatory, targeting dendritic spines, with layer-specific differences.