Author

Javier Orihuel

Universidad Nacional de Educación a DistanciaORCID 0000-0003-3033-6536Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Organism:rat· 5 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:proteomics· 1

Frequent Co-Authors

Alejandro Higuera‐MatasiD· 4 shared Emilio AmbrosioiD· 4 shared Marcos UchaiD· 4 shared Roberto CapellániD· 4 shared Alberto MarcosiD· 2 shared David Roura‐MartíneziD· 2 shared Manuel DescoiD· 2 shared María Luisa Soto‐MontenegroiD· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersNeuroscience

Alejandro Higuera‐MatasORCID

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5 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 16, 2026

Maternal immune activation and peripubertal stress differentially disrupt glutamatergic, endocannabinoid, and neuromodulatory signalling in the adult rat dorsal hippocampus: implications for excitatory-inhibitory balance

Pablo C. Del Olmo, Charlene Nowotny, Mario F. Fraga…·Alejandro Higuera‐Matas

This study examines how maternal immune activation and peripubertal stress affect glutamatergic, endocannabinoid, and neuromodulatory signaling in the adult rat dorsal hippocampus, revealing disruptions in excitatory-inhibitory balance.

1 citation

ratproteomics

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NeurosciencebioRxivPreprintOct 11, 2021

Additive, synergic and antagonistic interactions between maternal immune activation and peripubertal stress in cocaine addiction-like behaviour, morphofunctional brain parameters and striatal transcriptome.

Roberto Capellán, Javier Orihuel, Alberto Marcos…·Alejandro Higuera‐Matas

This study investigates how maternal immune activation and peripubertal stress interact to influence cocaine addiction-like behavior and striatal transcriptome in rats.

1 citation

ratbulk RNA-seq

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NeurosciencePsychopharmacologyPeer-reviewedMar 25, 2021

Lack of effect of different pain-related manipulations on opioid self-administration, reinstatement of opioid seeking, and opioid choice in rats

David J. Reiner, E. Andrew Townsend, Javier Orihuel…·Sidney Stevens Negus

This study shows that pain-related manipulations in rats do not increase opioid self-administration, reinstatement of seeking, or choice over food.

31 citations

ratexperimental assay

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NeurosciencebioRxivPreprintOct 19, 2020

Testing The Role Of Δ9-Tetrahydrocannabinol During Adolescence As A Gateway Drug: Behavioural, Brain Imaging And Transcriptomic Studies

Javier Orihuel, Roberto Capellán, David Roura‐Martínez…·Alejandro Higuera‐Matas

This study examines the effects of adolescent THC exposure on behavior, brain structure, and gene expression in rats, finding altered psychological and brain development but no clear support for the Gateway Hypothesis.

DOI 10.1101/2020.10.19.345322

ratbulk RNA-seq

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NeurosciencebioRxivPreprintMay 19, 2019

Ex vivo 1H-MRS brain metabolic profiling in a two-hit model of schizophrenia-related alterations: effects of prenatal immune activation and peripubertal stress.

Roberto Capellán, Mario Moreno, Javier Orihuel…·Alejandro Higuera‐Matas

This study uses ex vivo 1H-MRS to identify metabolic changes in a two-hit schizophrenia model, showing LPS and stress effects on brain metabolites.

1 citation

ratexperimental assay

𝕏 PostBluesky