Author

Ryan Q. Notti

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-9197-6134Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Christopher Austin KlebanoffiD· 1 shared Fei YiiD· 1 shared Henrik MolinaiD· 1 shared Martin W. BushiD· 1 shared Pujita DasiD· 1 shared Søren HeisseliD· 1 shared Thomas WalziD· 1 shared Zaki MolviiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperBiochemistry

Christopher Austin KlebanoffORCID

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1 paper

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedDec 16, 2025

The resting and ligand-bound states of the membrane-embedded human T-cell receptor-CD3 complex

Ryan Q. Notti, Fei Yi, Søren Heissel…·Thomas Walz

This study presents cryo-EM structures of the human TCR-CD3 complex in its resting and ligand-bound states, revealing conformational changes and the importance of native lipid environments.

32 citationstop 2%

humancryo-EM

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