ImmunologyNature CancerPeer-reviewed
CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit
Fei Yi, Tal Cohen, Natalie Zimmerman…·Christopher Austin Klebanoff
This study identifies FASLG expression patterns and shows that FAS-L/FAS auto-regulation governs CAR-T and CAR-NK cell persistence, enhancing antitumor efficacy when FAS is inhibited.