Author

Brigitte C. Widemann

National Cancer InstituteORCID 0000-0002-9198-7175Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Aadel A. ChaudhuriiD· 1 shared AeRang KimiD· 1 shared Alexander C. PaniD· 1 shared Amber K. WeineriD· 1 shared Amy E. ArmstrongiD· 1 shared Andrea M. GrossiD· 1 shared Andrea Nicole LucasiD· 1 shared Angela C. HirbeiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Aadel A. ChaudhuriORCID

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2 papers

Recent·Most cited

Identification of DLK1, a Notch ligand, as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma

Nai-Yun Sun, Suresh Kumar, Yoo Sun Kim, Diana Grace Varghese, Arnulfo Mendoza, Rosa Nguyen, Reona Okada, Karlyne M. Reilly, Brigitte C. Widemann, Yves G. Pommier, Fathi Elloumi, Anjali Dhall, Daiki Taniyama, Mayank Patel, Etan R. Aber, , Nitin Roper

This paper identifies DLK1 as a novel immunotherapeutic target in adrenocortical carcinoma, showing it regulates tumor cell plasticity and chemoresistance, and demonstrates the efficacy of a DLK1-targeting antibody-drug conjugate.

Nature Communications · Jul 1, 2025Peer-reviewedCancer Biology

Early detection of malignant and pre-malignant peripheral nerve tumors using cell-free DNA fragmentomics

R. Taylor Sundby, Jeffrey J. Szymanski, Alexander C. Pan, Paul A. Jones, Sana Z Mahmood, Olivia H. Reid, Divya Srihari, Amy E. Armstrong, Stacey Chamberlain, Sanita Burgic, Kara Weekley, Béga Murray, S. G. Patel, Faridi Qaium, Andrea Nicole Lucas, , Jack F. Shern

This study uses plasma cfDNA fragmentomics to distinguish malignant, pre-malignant, and non-malignant NF1-associated peripheral nerve sheath tumors.

Clinical Cancer Research · Aug 2, 2024Peer-reviewedGenetic & Genomic Medicine