Identification of DLK1, a Notch ligand, as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma
Nai-Yun Sun, Suresh Kumar, Yoo Sun Kim, Diana Grace Varghese, Arnulfo Mendoza, Rosa Nguyen, Reona Okada, Karlyne M. Reilly, Brigitte C. Widemann, Yves G. Pommier, Fathi Elloumi, Anjali Dhall, Daiki Taniyama, Mayank Patel, Etan R. Aber, , Nitin Roper
This paper identifies DLK1 as a novel immunotherapeutic target in adrenocortical carcinoma, showing it regulates tumor cell plasticity and chemoresistance, and demonstrates the efficacy of a DLK1-targeting antibody-drug conjugate.
Nature Communications · Jul 1, 2025Peer-reviewedCancer Biology