Cryo-EM Structure of the Cyclase Domain and Evaluation of Substrate Channeling in a Bifunctional Class II Terpene Synthase
Matthew N. Gaynes, Kollin C. Schultz, Eliott S. Wenger, Trey A. Ronnebaum, Ronen Marmorstein, David W. Christianson
The paper reports the cryo-EM structure of a fungal class II terpene synthase cyclase domain and shows substrate channeling between its prenyltransferase and cyclase functions.
Biochemistry · Oct 17, 2025Peer-reviewedBiochemistry