Eliott S. Wenger

This paper investigates the catalytic mechanism of hyoscyamine 6β-hydroxylase, revealing that metal coordination dynamics govern selectivity between hydroxylation and epoxidation reactions.

The paper reports the cryo-EM structure of a fungal class II terpene synthase cyclase domain and shows substrate channeling between its prenyltransferase and cyclase functions.

The paper presents the first structure of a bifunctional terpene synthase, revealing its architecture and suggesting how GGPP might be transferred between domains.

This study shows that substrate channeling in PaFS occurs without a flexible linker or covalent domain linkage, and that cyclase domains associate with the prenyltransferase octamer for optimal channeling.