Development and Characterization of a Tunable PDMS Substrate Model for Investigating Elastic Properties and Mechanical Stretching in Intervertebral Disc Cells
Johannes Hasler, Mikkael Lamoca, Kory Schimmelpfennig, Shuhuan Zhang, Wolfgang Hitzl, Sami Farajollahi, Vinay V. Abhyankar, Christopher L. Lewis, Rui Liu, Karin Wuertz‐Kozak
This paper develops a tunable PDMS substrate platform to study mechanical loading and cell-substrate interactions in intervertebral disc cells, showing cells align with applied strain and maintain viability.
JOR Spine · Dec 1, 2025Peer-reviewedBioengineering