HCV infection induces ubiquitin-dependent degradation of LATS1, inactivating the Hippo pathway and upregulating transcription of the CYR61 and CTGF genes
Maria Alethea Septianastiti, Chieko Matsui, Zihan Xu, Fransisca Puspitasari, Dewa Nyoman Murti Adyaksa, Lin Deng, Takayuki Abe, Ikuo Shoji
This study shows HCV infection causes LATS1 degradation via ubiquitin-mediated proteasomal pathway, inactivating the Hippo pathway and increasing CYR61 and CTGF gene transcription.
Journal of General Virology · Feb 5, 2026Peer-reviewedMicrobiology