Daniela Moreira Mombach

Transposable elements shape olaparib response according to BRCA1 status in triple-negative breast cancer

This paper shows that olaparib treatment increases transposable element activity in BRCA1-deficient triple-negative breast cancer cells, leading to genomic instability and immune responses.

TEscape: Defining the human transposable element transcriptome using multiplatform long-read sequencing

TEscape uses long-read sequencing to comprehensively annotate the human transposable element transcriptome, identifying over 83,000 previously unannotated isoforms.

Processed pseudogenes as dynamic substrates of vertebrate genome evolution

The paper shows processed pseudogenes are dynamic evolutionary elements, not inert, and links their abundance to life-history traits and cancer-related dynamics across vertebrates.