Carlos Mendez‐Dorantes

This paper shows that olaparib treatment increases transposable element activity in BRCA1-deficient triple-negative breast cancer cells, leading to genomic instability and immune responses.

The paper investigates how L1 retrotransposition intermediates can recombine with DNA breaks or other L1 insertions to form chromosomal rearrangements, showing dependence on ORF2p and BRCA1.

This study uses whole-genome sequencing to show that LINE-1 retrotransposition directly causes chromosomal rearrangements and instability in cancer genomes.