Pieter Spealman

This study identifies key glycoprotein residues that enhance the efficacy of a CCHFV vaccine by modulating cleavage and fusogenicity in animal models.

TEscape uses long-read sequencing to comprehensively annotate the human transposable element transcriptome, identifying over 83,000 previously unannotated isoforms.

The paper examines how bacterial, fungal, and functional diversity influence the distribution of antibiotic resistance genes in a hay field, finding that clinical ARG diversity is more linked to fungal diversity than bacterial diversity.

This study shows segmental copy number amplifications are more stable than aneuploidies when selection pressure is removed, with aneuploidies reverting quickly and losing fitness.

The paper investigates the multi-layered repression system controlling C9ORF72 translation and identifies strategies to rescue loss-of-function in disease.

The paper examines gene expression changes in yeast strains with adaptive copy-number variants, finding correlations between CNVs and transcript abundance, but reduced proteomic effects due to post-transcriptional compensation.

The paper investigates how copy number variants (CNVs) in yeast affect mutational tolerance and fitness, finding both increased tolerance in translation-related genes and decreased tolerance in mitochondrial function genes.

The paper identifies that nanopore sequencing fails catastrophically at inverted duplicated DNA sequences, leading to incorrect base calls due to elevated current levels.