The paper identifies eQTLs and eGenes in tonsil-derived immune cells from children, linking them to childhood atopic diseases and expanding known genetic contributors.

Journal of Allergy and Clinical Immunology · Aug 1, 2026Peer-reviewedImmunology

CD4+ Trm sustain the chronic phase of auto-immune neuroinflammatory disease

Aurora Pignata, David Frieser, Carmen Gonzalez-Fierro, Cheng‐Chih Hsiao, Hendrik J. Engelenburg, Marine Alis, Ilan Fijalkow, Vincent Cazaentre, Lucie Nozeran, Romain Miranda-Capet, Eloïse Dufourd, Thaïs Vermeulen, Amel Aïda, Carole Le Coz, Klaas P. J. M. van Gisbergen, , Frédérick Masson

This study identifies CD4+ Trm cells in the CNS of PMS patients and EAE models, showing their role in sustaining chronic inflammation and suggesting targeting them for new therapies.

Science Translational Medicine · Jul 23, 2025Peer-reviewedImmunology

Human follicular helper T cell promoter connectomes reveal novel genes and regulatory elements at SLE GWAS loci

Chun Su, Matthew E. Johnson, Annabel Torres, Rajan M. Thomas, Elisabetta Manduchi, Prabhat Kumar Sharma, Carole Le Coz, Michelle E. Leonard, Sumei Lu, Kenyaita M. Hodge, Alessandra Chesi, James A. Pippin, Neil D. Romberg, Struan F.A. Grant, Andrew D. Wells

This paper identifies functional variants and regulatory elements at SLE GWAS loci using 3D chromatin maps of TFH cells, revealing novel genes and regulatory interactions.

bioRxiv · Dec 20, 2019 · PreprintGenomics