Hendrik J. Engelenburg

The paper identifies foamy microglia as contributors to disease progression in secondary progressive MS, linking oxylipins to lesion expansion and proposing monoacylglycerol lipase as a therapeutic target.

This study identifies meningeal monocyte-derived macrophages as drivers of progressive multiple sclerosis using single-cell and spatial transcriptomics.

This study identifies CD4+ Trm cells in the CNS of PMS patients and EAE models, showing their role in sustaining chronic inflammation and suggesting targeting them for new therapies.

The paper examines microglia nodules in multiple sclerosis and finds they are associated with higher lesion load and specific gene expression changes compared to stroke.

This study investigates how early-life stress and dietary omega-6/omega-3 ratios affect hippocampal mRNA and miRNA expression in adulthood, revealing molecular pathways involved in cognitive function and inflammation.