CD4+ Trm sustain the chronic phase of auto-immune neuroinflammatory disease
Aurora Pignata, David Frieser, Carmen Gonzalez-Fierro, Cheng‐Chih Hsiao, Hendrik J. Engelenburg, Marine Alis, Ilan Fijalkow, Vincent Cazaentre, Lucie Nozeran, Romain Miranda-Capet, Eloïse Dufourd, Thaïs Vermeulen, Amel Aïda, Carole Le Coz, Klaas P. J. M. van Gisbergen, , Frédérick Masson
This study identifies CD4+ Trm cells in the CNS of PMS patients and EAE models, showing their role in sustaining chronic inflammation and suggesting targeting them for new therapies.
Science Translational Medicine · Jul 23, 2025Peer-reviewedImmunology