Frédérick Masson

CD4+ Trm sustain the chronic phase of auto-immune neuroinflammatory disease

This study identifies CD4+ Trm cells in the CNS of PMS patients and EAE models, showing their role in sustaining chronic inflammation and suggesting targeting them for new therapies.

Id2 levels determine the development of effector vs. exhausted tissue-resident memory CD8+ T cells during CNS chronic infection

Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling

This study shows that latent Toxoplasma gondii infection reduces visceral nociception in mice via peripheral opioid receptor signaling, suggesting a potential negative link with abdominal pain in humans.

Protective function and differentiation cues of brain-resident CD8+ T cells during immune surveillance of chronic latent Toxoplasma gondii infection

This study identifies the protective functions and differentiation cues of brain-resident CD8+ T cells during chronic Toxoplasma gondii infection using a mouse model and single-cell transcriptomics.