Klaas P. J. M. van Gisbergen

This study identifies CD4+ Trm cells in the CNS of PMS patients and EAE models, showing their role in sustaining chronic inflammation and suggesting targeting them for new therapies.

This study shows that SPPL3 in tumor cells affects innate immune responses by modulating nsGSLs, reducing susceptibility to neutrophils, NK cells, and γδ T cells.

This study identifies the protective functions and differentiation cues of brain-resident CD8+ T cells during chronic Toxoplasma gondii infection using a mouse model and single-cell transcriptomics.