Cancer BiologyAPOPTOSISPeer-reviewed
KRAS-Mediated CCDC6 Degradation Drives xCT Upregulation and Ferroptosis Evasion
Daniela Criscuolo, Rosaria Catalano, Carmela Baviello…·Angela Celetti
This study identifies a KRAS/CCDC6/xCT signaling axis that promotes ferroptosis resistance in KRAS-mutated cancers by inhibiting CCDC6 degradation, which enhances ATF4 activity and xCT expression.
DOI 10.1007/s10495-026-02400-4