Author

Daniela Criscuolo

Institute for Experimental Endocrinology and OncologyORCID 0000-0002-7581-0169Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Angela CelettiiD· 2 shared Carmela BavielloiD· 2 shared Francesco MerollaiD· 2 shared Maria MarottaiD· 2 shared Rosaria CatalanoiD· 2 shared Alexandra IngallinellaiD· 1 shared Anna SpinaiD· 1 shared Antonino Iaccarino· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Angela CelettiORCID

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2 papers

Recent·Most cited

KRAS-Mediated CCDC6 Degradation Drives xCT Upregulation and Ferroptosis Evasion

Daniela Criscuolo, Rosaria Catalano, Carmela Baviello, Claudia Fioravanti, Elena Vigliar, Francesco Morra, Maria Marotta, Junsei Mimura, Antonino Iaccarino, Francesco Pepe, Dorina Belotti, Giancarlo Troncone, Francesco Merolla, Rosa Marina Melillo, Angela Celetti

This study identifies a KRAS/CCDC6/xCT signaling axis that promotes ferroptosis resistance in KRAS-mutated cancers by inhibiting CCDC6 degradation, which enhances ATF4 activity and xCT expression.

APOPTOSIS · Jul 14, 2026Peer-reviewedCancer Biology

Using CCDC6 immunostaining in conjunction with the RAD51 HRD assay as a novel approach to expand PARPi treatment eligibility in HGSOC patients

Daniela Criscuolo, Francesco Merolla, Benedetta Pellegrino, Luca Russolillo, Ilaria De Benedictis, Daniela Califano, Rosaria Catalano, Carmela Baviello, Silvia Varricchio, Sabrina Chiara Cecere, Camilla Nero, Eleonora Palluzzi, Dyonissios Katsaros, E. Capoluongo, Giovanni Luca Scaglione, , Angela Celetti

The paper investigates CCDC6 mutations in HGSOC and shows their link to HRD and PARPi sensitivity, even in BRCA1/2 wild-type patients.

bioRxiv · Jul 29, 2025 · PreprintCancer Biology