Francesco Merolla

This study identifies a KRAS/CCDC6/xCT signaling axis that promotes ferroptosis resistance in KRAS-mutated cancers by inhibiting CCDC6 degradation, which enhances ATF4 activity and xCT expression.

The paper investigates CCDC6 mutations in HGSOC and shows their link to HRD and PARPi sensitivity, even in BRCA1/2 wild-type patients.

This paper presents a framework for integrating deep-learning models into the laboratory information system using open-source tools and HL7 standards to support clinical adoption in digital pathology.