Thomas Konstantinovsky

A computable probability landscape for T cell receptor repertoire sampling and comparison

The paper introduces BEAM, a probability model for TCRβ sequences that enables depth-aware sampling calculations and interpretable repertoire comparison.

An unbiased comparison of immunoglobulin sequence aligners

The paper introduces GenAIRR, a simulation framework for Ig sequences, and evaluates aligners to identify their performance characteristics, establishing a benchmarking standard for Ig sequence alignment.

Epigenetic aging waves:Artificial intelligence detects clustering of switch points in DNA methylation rate in defined sex-dependent age periods

The paper uses machine learning to identify age-related switch points in DNA methylation trends, revealing three sex-dependent waves of epigenetic aging.

Deconvolution of the epigenetic age discloses distinct inter-personal variability in epigenetic aging patterns

The paper deconvolves epigenetic age to identify CpG sites responsible for accelerated and decelerated aging, revealing inter-personal variability in aging patterns.