Interplay of condensation and chromatin binding underlies BRD4 targeting
Amy R. Strom, Jorine M. Eeftens, Yury Polyachenko, Claire J. Weaver, Hans-Frederick Watanabe, Dan Bracha, Natalia D. Orlovsky, Chanelle C. Jumper, William M. Jacobs, Clifford P. Brangwynne
This study investigates how BRD4 chromatin binding modulates its condensate formation, showing that chromatin interactions influence both kinetic and thermodynamic properties of BRD4 condensation.
Molecular Biology of the Cell · Apr 24, 2024Peer-reviewedMolecular Biology