The ASC inflammasome adapter controls the extent of peripheral protein aggregate deposition in inflammation-associated amyloidosis
Marco Losa, Marc Emmenegger, Pierre De Rossi, Patrick M. Schürch, Tetiana Serdiuk, Niccolò Pengo, Danaëlle Capron, Dimitri Bieli, Niels J. Rupp, Manfredi C. Carta, Karl Frontzek, Veronika Lysenko, Regina Reimann, Asvin KK Lakkaraju, Mario Nuvolone, , Adriano Aguzzi
This paper shows that ASC controls AA amyloidosis by interacting with SAA and that anti-ASC antibodies reduce amyloid loads in mice.
bioRxiv · May 1, 2021 · PreprintMolecular Biology