Author

Alexandre P. A. Theocharides

University Hospital ZurichORCID 0000-0002-1535-8692Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Adriano AguzziiD· 2 shared Manfredi C. CartaiD· 2 shared Marc EmmeneggeriD· 2 shared Marco LosaiD· 2 shared Veronika LysenkoiD· 2 shared Alessandra Carrella· 1 shared Alessandro CrimiiD· 1 shared Alice GhidiniiD· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersNeuroscience

Adriano AguzziORCID

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Author profile →

4 papers

Recent·Most cited

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of a-synuclein

Eleanna Kara, Alessandro Crimi, Anne E. Wiedmer, Marc Emmenegger, Claudia Manzoni, Sara Bandrés‐Ciga, Karishma D’Sa, Regina Hertfelder Reynolds, Juan Antonio Botía, Marco Losa, Veronika Lysenko, Manfredi C. Carta, Daniel Heinzer, Merve Avar, Andra Chincisan, , Adriano Aguzzi

The paper identifies 38 genes regulating a-synuclein cell-to-cell transfer using an siRNA screen and shows genetic overlap with Parkinson's disease.

Cell Reports · Jun 1, 2021Peer-reviewedNeuroscience

The ASC inflammasome adapter controls the extent of peripheral protein aggregate deposition in inflammation-associated amyloidosis

Marco Losa, Marc Emmenegger, Pierre De Rossi, Patrick M. Schürch, Tetiana Serdiuk, Niccolò Pengo, Danaëlle Capron, Dimitri Bieli, Niels J. Rupp, Manfredi C. Carta, Karl Frontzek, Veronika Lysenko, Regina Reimann, Asvin KK Lakkaraju, Mario Nuvolone, , Adriano Aguzzi

This paper shows that ASC controls AA amyloidosis by interacting with SAA and that anti-ASC antibodies reduce amyloid loads in mice.

bioRxiv · May 1, 2021 · PreprintMolecular Biology

Delivery of oligonucleotides to bone marrow to modulate ferrochelatase splicing in a mouse model of Erythropoietic Protoporphyria

François Halloy, Pavithra S. Iyer, Paulina Ćwiek, Alice Ghidini, Jasmin Barman‐Aksözen, Nicole Wildner-Verhey van Wijk, Alexandre P. A. Theocharides, Elisabeth Irene Minder, Xiaoye Schneider‐Yin, Daniel Schümperli, Jonathan Hall

This study evaluates splice-switching oligonucleotides (SSOs) in a mouse model of Erythropoietic Protoporphyria, showing that an SSO with a cholesteryl group increases correctly spliced FECH transcript by 80% in bone marrow.

Nucleic Acids Research · Apr 9, 2020Peer-reviewedMolecular Biology

Ultra-sensitive proteome profiling of FACS-isolated cell populations by data-independent acquisition-MS: Application to human hematopoietic stem and progenitor cells

Sabine Amon, Fabienne Meier‐Abt, Ludovic C. J. Gillet, Slavica Dimitrieva, Alexandre P. A. Theocharides, Markus Gabriel Manz, Ruedi H. Aebersold

The paper describes an ultra-sensitive mass spectrometry method for proteomic analysis of FACS-isolated human hematopoietic stem and progenitor cells, revealing unique proteomic signatures and stemness-related biochemical processes.

bioRxiv · Jul 17, 2018 · PreprintSystems Biology