Dimitri Bieli

In situ mutational screening and CRISPR interference define apterous cis-regulatory inputs during compartment boundary formation

The paper identifies cis-regulatory elements controlling apterous expression during Drosophila wing compartment boundary formation using CRISPR interference and mutational analysis.

Genetic characterization of the apterous Life Span Enhancer in Drosophila melanogaster

The paper identifies and functionally characterizes a novel cis-regulatory element, apLSE, essential for hindgut morphogenesis and adult survival in Drosophila melanogaster.

In vivo regulation of fluorescent fusion proteins by engineered kinases

The paper develops engineered kinases to specifically phosphorylate fluorescent protein fusions in vivo, demonstrating their use in studying actomyosin activation in Drosophila embryos.

Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc

The paper shows that Dpp/BMP morphogen dispersal is not strictly required for overall wing patterning and growth in Drosophila, challenging a long-standing dogma.

The ASC inflammasome adapter controls the extent of peripheral protein aggregate deposition in inflammation-associated amyloidosis

This paper shows that ASC controls AA amyloidosis by interacting with SAA and that anti-ASC antibodies reduce amyloid loads in mice.

Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin/F-actin based oscillatory ratchet mechanism

The paper identifies junction-based lamellipodia (JBL) as structures driving endothelial cell movement during vascular remodeling, showing their dependence on F-actin and VE-cadherin.

A nanobody-based toolset to investigate the role of protein localization and dispersal in Drosophila

The paper introduces a nanobody-based toolset, GrabFP, to manipulate protein localization and dispersal in Drosophila cells and demonstrates its use in studying Dpp protein gradient formation.