Author

Tyce J. Kearl

Medical College of WisconsinORCID 0000-0002-9255-892XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Aicha E. QuamineiD· 1 shared Amani A. GilletteiD· 1 shared Anastasia A Griggs· 1 shared Angela Hsu· 1 shared Bryon D. JohnsoniD· 1 shared Chloe A King· 1 shared Christian M. CapitiniiD· 1 shared Cole Weaver· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Aicha E. QuamineORCID

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2 papers

Recent·Most cited

Autofluorescence imaging reveals the impact of cryopreservation on T cell metabolism and activation response

Dan L. Pham, Meghana Kalluri, Cole Weaver, Angela Hsu, Amani A. Gillette, Wenxuan Zhao, Tyce J. Kearl, Peiman Hematti, Nirav Niranjan Shah, Melissa C. Skala

This study uses optical metabolic imaging to assess how cryopreservation affects T cell metabolism and activation, finding delayed responses and identifying metabolically-fit cells linked to viability.

Molecular Therapy Advances · Feb 19, 2026Peer-reviewedImmunology

TIM-3 blockade enhances ex vivo stimulated allogeneic NK cell therapy for relapsed murine neuroblastoma after hematopoietic cell transplant

Aicha E. Quamine, Evan L. Dray, Nicholas R Mohrdieck, Chloe A King, Anastasia A Griggs, Jillian M Kline, Monica M. Cho, S. P. Rinella, Katharine E. Tippins, Paul D. Bates, Lei Shi, Longzhen Song, Nicholas J Hess, Tyce J. Kearl, Bryon D. Johnson, Christian M. Capitini

This study shows that combining TIM-3 blockade with ex vivo stimulated allogeneic NK cells improves survival and reduces tumor growth in a murine neuroblastoma model after allo-HCT without increasing GVHD.

Journal for ImmunoTherapy of Cancer · Dec 1, 2025Peer-reviewedImmunology