mTOR drives cerebrovascular dysfunction and blood-brain barrier breakdown in a model of Alzheimers disease with cerebral amyloid angiopathy
Candice E. Van Skike, Lauren R. Miller, Stephen F. Hernandez, Stacy A. Hussong, Haneen Makhlouf, Aishwarya Muppala, Nicholas DeRosa, Jordan B. Jahrling, Kelly T. Dineley, Verónica Galván
This study shows that mTOR inhibition reduces cerebrovascular Aβ accumulation and improves cognitive function in a mouse model of Alzheimer's disease with cerebral amyloid angiopathy.
bioRxiv · Sep 7, 2026 · PreprintNeuroscience