Author

Nicholas DeRosa

The University of Texas at San Antonio Health Science Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Organism:rat· 1

Frequent Co-Authors

Aishwarya Muppala· 1 shared Candice E. Van SkikeiD· 1 shared Damian LozanoiD· 1 shared Deborah M. HolsteiniD· 1 shared Elizabeth S. FisheriD· 1 shared Gerard Nickel· 1 shared Haneen MakhloufiD· 1 shared James Donald LechleiteriD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Aishwarya Muppala

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2 papers

Recent·Most cited

mTOR drives cerebrovascular dysfunction and blood-brain barrier breakdown in a model of Alzheimers disease with cerebral amyloid angiopathy

Candice E. Van Skike, Lauren R. Miller, Stephen F. Hernandez, Stacy A. Hussong, Haneen Makhlouf, Aishwarya Muppala, Nicholas DeRosa, Jordan B. Jahrling, Kelly T. Dineley, Verónica Galván

This study shows that mTOR inhibition reduces cerebrovascular Aβ accumulation and improves cognitive function in a mouse model of Alzheimer's disease with cerebral amyloid angiopathy.

bioRxiv · Sep 7, 2026 · PreprintNeuroscience

Adenosine A1R/A3R Agonist AST-004 Reduces Brain Infarction in Mouse and Rat Models of Acute Ischemic Stroke

Elizabeth S. Fisher, Yanan Chen, Mikaela M. Sifuentes, Jeremy J. Stubblefield, Damian Lozano, Deborah M. Holstein, JingMei Ren, Matthew S. Davenport, Nicholas DeRosa, Tsung-pei Chen, Gerard Nickel, Theodore E. Liston, James Donald Lechleiter

This study shows AST-004, an A1R/A3R agonist, reduces brain infarction in mouse and rat stroke models, with efficacy dependent on A3R signaling and astrocyte mitochondrial metabolism.

Frontiers in Stroke · Nov 22, 2022Peer-reviewedNeuroscience