Lower cortical FKBP5 DNA methylation at key enhancer sites is associated with older age and higher gene expression in schizophrenia
Katrina Z. Edmond, Dominic Kaul, Natan Yusupov, Maik Ködel, Susann Sauer, Anna Sophie Fröhlich, Ran N. Tao, Joel E. Kleinman, Daniel R. Weinberger, Thomas M. Hyde, Darina Czamara, Elisabeth B. Binder, Natalie Matosin
The paper examines FKBP5 DNA methylation in schizophrenia and finds lower methylation in a proximal enhancer linked to higher gene expression and age.
bioRxiv · Jan 28, 2025 · PreprintNeuroscience