Maik Ködel

Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids

This study shows chronic glucocorticoid exposure alters lineage specification in human neural organoids by priming inhibitory neuron fate through transcription factors like PBX3.

Lower cortical FKBP5 DNA methylation at key enhancer sites is associated with older age and higher gene expression in schizophrenia

The paper examines FKBP5 DNA methylation in schizophrenia and finds lower methylation in a proximal enhancer linked to higher gene expression and age.

Differential Dynamics and Roles of FKBP51 Isoforms and Their Implications for Targeted Therapies

This study investigates the differential dynamics and roles of FKBP51 isoforms in response to glucocorticoids using in vitro models and human blood cells, highlighting their distinct functions and implications for targeted therapies.

Human neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression

This study shows glucocorticoids increase specific basal progenitors via ZBTB16, leading to more neurons and linking to educational attainment and brain structure.

Stress-induced brain responses are associated with BMI in women

The paper examines how stress-induced brain responses relate to BMI in women, finding that specific brain regions predict BMI and that endocrine factors, not inflammation, are linked to these changes.

Assessment of glucocorticoid-induced enhancer activity of eSNP regions using STARR-seq reveals novel molecular mechanisms in psychiatric disorders

Associations of psychiatric disease and aging on FKBP5 expression converge on cortical supragranular neurons

The paper investigates how psychiatric disease and aging affect FKBP5 expression in the human brain, identifying supragranular neurons as key targets.

Cell-type specific impact of glucocorticoid receptor activation on the developing brain

The paper investigates how glucocorticoid receptor activation affects neuronal development in fetal human brain organoids using single-cell transcriptomics, finding cell-type specific impacts on differentiation and behavior-related gene expression.

Epigenetic derepression of FKBP5 by aging and stress contributes to NF-kB-driven inflammation and cardiovascular risk

The paper identifies FKBP5 epigenetic derepression by aging and stress as a driver of NF-kB-driven inflammation and cardiovascular risk through in vitro and cohort studies.

HAM-TBS: High accuracy methylation measurements via targeted bisulfite sequencing

HAM-TBS provides a high-accuracy, cost-effective method for measuring DNA methylation in specific genomic regions using targeted bisulfite sequencing.