Author

Susann Sauer

Max Planck Institute of Psychiatry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4 Genetics· 2 Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 7 Research Focus:differential expression· 6 Organism:human· 5 Research Focus:gene regulatory network inference· 4 Assay:bulk RNA-seq· 3 Assay:DNA methylation· 3 Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Elisabeth B. BinderiD· 8 shared Darina CzamaraiD· 5 shared Maik Ködel· 5 shared Simone RoehiD· 5 shared Anthi C. KrontiraiD· 3 shared Cristiana CruceanuiD· 3 shared Janine ArlothiD· 3 shared Monika Rex‐Haffner· 3 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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8 shared papersNeuroscience

Elisabeth B. BinderORCID

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8 papers

Recent·Most cited

Multilevel sex-specific neurobiological signatures of early life adversity

Sowmya V. Narayan, Christina Beer, Carlo Castoldi, Tibor Štark, Beatrice Dal Bianco, Simone Röh, Susann Sauer, Joeri Bordes, Stoyo Karamihalev, Shiladitya Mitra, Veronika Kovářová, Patrícia Maidana Miguel, Bonnie Alberry, Darina Czamara, Patricia Pelufo Silveira, , Mathias V. Schmidt

This study investigates how early life stress affects brain function and behavior in mice, revealing sex-specific differences in neurobiological outcomes.

bioRxiv · Jan 26, 2026 · PreprintNeuroscience

Lower cortical FKBP5 DNA methylation at key enhancer sites is associated with older age and higher gene expression in schizophrenia

Katrina Z. Edmond, Dominic Kaul, Natan Yusupov, Maik Ködel, Susann Sauer, Anna Sophie Fröhlich, Ran N. Tao, Joel E. Kleinman, Daniel R. Weinberger, Thomas M. Hyde, Darina Czamara, Elisabeth B. Binder, Natalie Matosin

The paper examines FKBP5 DNA methylation in schizophrenia and finds lower methylation in a proximal enhancer linked to higher gene expression and age.

bioRxiv · Jan 28, 2025 · PreprintNeuroscience

Huntingtin CAG repeat size variations outside the Huntington's disease complex: associations with depression and anxiety phenotypes and basal ganglia structure

Magdalena Vater, Nicolas Rost, Gertrud Eckstein, Susann Sauer, Alina Tontsch, Angelika Erhardt, Susanne Lucae, Tanja Maria Brückl, Thomas Klopstock, Philipp G. Sämann, Elisabeth B. Binder

This study investigates the association between HTT CAG repeat size variations and psychiatric phenotypes and basal ganglia structure in non-HD ranges, finding age-dependent effects on anxiety and depression risk.

bioRxiv · May 22, 2024 · PreprintGenetics

Human neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression

Anthi C. Krontira, Cristiana Cruceanu, Leander Dony, Christina Kyrousi, Marie-Helen Link, Nils Rek, Dorothee Pöhlchen, Catarina Raimundo, Signe Penner-Goeke, Alicia M. Schowe, Darina Czamara, Marius Lahti‐Pulkkinen, Sara Sammallahti, Elina Wolford, Kati Heinonen, , Elisabeth B. Binder

This study shows glucocorticoids increase specific basal progenitors via ZBTB16, leading to more neurons and linking to educational attainment and brain structure.

Neuron · Mar 4, 2024Peer-reviewedNeuroscience

DiffBrainNet: differential analyses add new insights into the response to glucocorticoids at the level of genes, networks and brain regions

Nathalie Gerstner, Anthi C. Krontira, Cristiana Cruceanu, Simone Roeh, Benno Pütz, Susann Sauer, Monika Rex‐Haffner, Mathias V. Schmidt, Elisabeth B. Binder, Janine Arloth

The paper introduces DiffBrainNet, a framework combining differential expression and network analysis to study glucocorticoid responses in mouse brain regions, revealing gene-level and network-level insights.

Neurobiology of Stress · Oct 14, 2022Peer-reviewedGenomics

Assessment of glucocorticoid-induced enhancer activity of eSNP regions using STARR-seq reveals novel molecular mechanisms in psychiatric disorders

Signe Penner-Goeke, Melissa Bothe, Nils Kappelmann, Peter Kreitmaier, Ezgi Kaya, Dorothee Pöhlchen, Anne Kühnel, Darina Czamara, BeCOME working group, Laura V. Glaser, Simone Roeh, Maik Ködel, Jose Luis Monteserin Garcia, Christine Rummel, Janine Arloth, , Elisabeth B. Binder

medRxiv · May 18, 2022 · PreprintGenetic & Genomic Medicine

Cell-type specific impact of glucocorticoid receptor activation on the developing brain

Cristiana Cruceanu, Leander Dony, Anthi C. Krontira, David S. Fischer, Simone Roeh, Rossella Di Giaimo, Christina Kyrousi, Janine Arloth, Darina Czamara, Silvia Martinelli, Stefanie Wehner, Michael S. Breen, Maik Ködel, Susann Sauer, Monika Rex‐Haffner, , Elisabeth B. Binder

The paper investigates how glucocorticoid receptor activation affects neuronal development in fetal human brain organoids using single-cell transcriptomics, finding cell-type specific impacts on differentiation and behavior-related gene expression.

bioRxiv · Jan 9, 2020 · PreprintNeuroscience

HAM-TBS: High accuracy methylation measurements via targeted bisulfite sequencing

Simone Roeh, Tobias Wiechmann, Susann Sauer, Maik Ködel, Elisabeth B. Binder, Nadine Provençal

HAM-TBS provides a high-accuracy, cost-effective method for measuring DNA methylation in specific genomic regions using targeted bisulfite sequencing.

Epigenetics & Chromatin · Jul 4, 2018Peer-reviewedGenetics