High regeneration-associated stress defines a distinct HCC subgroup with therapeutically exploitable vulnerabilities
Nina Desboeufs, Peter Leary, Chenhui Zhao, Sarah Kollar, Lap Kwan Chan, Lara Planas‐Paz, André Fitsche, Alexander Schmidt, Fabiola Prutek, Katja R Baumann, S. Schneebeli, Susanne Dettwiler, Federico Donà, Reha Akpinar, Luigi Terracciano, , Achim Weber
This paper identifies a distinct HCC subgroup defined by high regeneration-associated stress, showing vulnerability to ATR inhibitors and proposing LIVRESS as a biomarker for treatment stratification.
bioRxiv · Aug 20, 2026 · PreprintCancer Biology