Peter Leary

This study identifies Wnt7b as a critical autocrine WNT ligand required for survival of BRAF-mutant colorectal cancer organoids and shows its association with poor patient survival in human tumors.

This paper identifies a distinct HCC subgroup defined by high regeneration-associated stress, showing vulnerability to ATR inhibitors and proposing LIVRESS as a biomarker for treatment stratification.

This study identifies a rostral hotspot in the medial nucleus accumbens shell regulated by D1-SPNs that controls hedonic feeding, introducing Stard5 as a molecular marker for targeted manipulation.

The paper shows that extrachromosomal circular DNA (eccDNA) from micronuclei promotes inflammation and hepatocellular carcinoma (HCC) development through the cGAS-STING pathway.

This study uses AI-based image analysis and multi-omics profiling to link morphological features with molecular changes in ccRCC, identifying unique molecular profiles in aggressive rhabdoid tumors.

prolfquapp simplifies differential expression analysis in quantitative proteomics by providing a command-line tool with dynamic HTML reports and integration with existing analysis tools.