Author

Lap Kwan Chan

University of ZurichORCID 0000-0002-9165-6982Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Achim WeberiD· 2 shared Nina DesboeufsiD· 2 shared Peter LearyiD· 2 shared Adrian Kobe· 1 shared Alexander SchmidtiD· 1 shared André Fitsche· 1 shared Andreas Emanuel KremeriD· 1 shared Anne‐Laure LeblondiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Achim WeberORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

NIK stabilization reprograms the pancreas toward chronic pancreatitis and pancreatic lipomatosis

Ziwei Du, Lilli Weber, Ulrike F.G. Buettner, Melanie Gerstenlauer, Uta Manfras, Katja Steiger, Thomas Metzler, Lap Kwan Chan, Medhanie Assmelash Mulaw, Miltiadis Tsesmelis, Thomas Wirth

This study shows that NIK stabilization causes chronic pancreatitis and pancreatic lipomatosis via RelB-dependent non-canonical NF-κB signaling.

bioRxiv · Oct 14, 2026 · PreprintCancer Biology

High regeneration-associated stress defines a distinct HCC subgroup with therapeutically exploitable vulnerabilities

Nina Desboeufs, Peter Leary, Chenhui Zhao, Sarah Kollar, Lap Kwan Chan, Lara Planas‐Paz, André Fitsche, Alexander Schmidt, Fabiola Prutek, Katja R Baumann, S. Schneebeli, Susanne Dettwiler, Federico Donà, Reha Akpinar, Luigi Terracciano, , Achim Weber

This paper identifies a distinct HCC subgroup defined by high regeneration-associated stress, showing vulnerability to ATR inhibitors and proposing LIVRESS as a biomarker for treatment stratification.

bioRxiv · Aug 20, 2026 · PreprintCancer Biology

Extrachromosomal circular DNA promotes inflammation and hepatocellular carcinoma development

Lap Kwan Chan, Juanjuan Shan, Elias Rodríguez-Fos, Marc Eammonn Healy, Peter Leary, Rossella Parrotta, Nina Desboeufs, Gabriel Semere, Nadine Wittstruck, Anton George Henssen, Achim Weber

The paper shows that extrachromosomal circular DNA (eccDNA) from micronuclei promotes inflammation and hepatocellular carcinoma (HCC) development through the cGAS-STING pathway.

Science Advances · Oct 17, 2025Peer-reviewedCancer Biology