Chantal Pauli

This paper identifies a distinct HCC subgroup defined by high regeneration-associated stress, showing vulnerability to ATR inhibitors and proposing LIVRESS as a biomarker for treatment stratification.

This study identifies SSc synovitis as an IFN-driven stromal condition distinct from RA, with implications for IFNAR1 blockade as a therapeutic strategy.

The paper identifies MTAP deficiency as a biomarker in lung neuroendocrine neoplasms, distinguishing carcinoids from SCLC and LCNEC, and shows it is not caused by 9p21 deletion or promoter hypermethylation.

This paper introduces PCF-SiM, a framework for quantifying spatial organization in multiplexed imaging data, demonstrating its application in detecting tissue remodeling and spatial interactions in disease models.

This study identifies disease-specific fibroblast-myeloid interactions in RA synovium, showing SPP1 signaling and fibroblast-myeloid-dendritic interactions drive RA inflammation by linking innate immunity to autoimmunity.

This study identifies PI5P4K as a regulator of iron homeostasis in pancreatic cancer cells, showing its role in metabolic fitness and tumor growth.

The paper optimizes a dissociation protocol for fresh synovial biopsies and creates a single-cell reference map of human synovium in inflammatory arthritis, revealing new cell types and functions.