Cell BiologyAdvanced SciencePeer-reviewed
A Vascular Dissection and Rupture Linked Metabolite Acts Via BLT2 Receptor
Yuyu Li, Jiaqi Yu, Weiyao Chen…·Yuan Wang
This study identifies 12-HETE as a key metabolite in thoracic aortic dissection (TAD) that activates BLT2 receptors on macrophages, driving inflammation and VSMC phenotype switching, and shows that targeting this pathway can reduce TAD progression.
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