Immunoregulatory gene GIMAP6 suppresses lethal atherosclerotic vasculopathy and ischemic heart failure
Xiang Chen, Kaja S. Arusha, Danielle Springer, Sachiko Nakamori, Jing Cui, Ping Du Jiang, Zhi-Hong Yang, Yu Zhang, Huie Jing, Ann Y. Park, Maria H Zhu, Sarah E. Weber, Deniz N Cağdaş, Hassan Abolhassani, Nasrin Behniafard, , Michael J. Lenardo
This study shows that GIMAP6 loss leads to inflammatory vasculopathy and atherosclerosis, causing heart failure and early death, and identifies GIMAP6 as a protective factor against cardiovascular disease.
Cell · Oct 1, 2026Peer-reviewedImmunology