G-quadruplex topologies determine the functional outcome of guanine-rich bioactive oligonucleotides
Prakash Kharel, Nupur Bhatter, Safiyah Noor Zubair, Shawn M. Lyons, Paul Anderson, Pavel V. Ivanov
This study shows that G-quadruplex topology determines the functional outcome of G-rich oligonucleotides, with parallel topologies inhibiting translation while antiparallel ones do not.
Nucleic Acids Research · Jun 12, 2025Peer-reviewedBiochemistry