Prakash Kharel

This study identifies tRNA-derived fragments (tRFs) as key regulators of Tau aggregation in Alzheimer's disease and shows their potential as therapeutic targets.

This study shows that G-quadruplex topology determines the functional outcome of G-rich oligonucleotides, with parallel topologies inhibiting translation while antiparallel ones do not.

This study identifies HOXDeRNA as a long non-coding RNA that derepresses glioma-specific transcription factors by interacting with PRC2 and RNA quadruplex structures, driving astrocyte transformation into glioma-like cells.

The paper identifies stress-induced RNA G-quadruplexes in human cells and shows they regulate mRNA stability and stress response.

The paper links NAT8L mRNA oxidation to reduced NAA levels and neurodegeneration in multiple sclerosis.