B Y Zhang

A provenance-tracked multi-agent system curated 57 CAR-T patient scRNA-seq studies, generated reviewable hypotheses, and prioritized KLRC1/NKG2A, whose blockade improved CD8+ CAR-T antitumour activity in a Raji xenograft model.

Pan-human Azimuth maps diverse human cells into a unified hierarchical typology, enabling cross-tissue comparisons and spatial transcriptomic annotation.

ClonoTrace integrates BCR sequences with transcriptomics to improve trajectory inference in B cell development and disease, identifying novel pathways in autoimmunity and aging.

This paper introduces STACAME, a framework for analyzing cross-species spatial transcriptomics data to identify shared and divergent tissue architectures across species.

The paper validates MHPC512, a special-purpose supercomputer for molecular dynamics simulations, showing it produces results consistent with established software.

This study generates and expands human pancreatic islet organoids in vitro, which can differentiate into multiple endocrine cell types and show therapeutic potential in animal models.

The paper develops an individualized TMS targeting approach for ASD based on functional connectivity to the posterior cingulate cortex, showing symptom reduction in a case series.

The paper maps the base-resolution DNA methylome of human MDS HSCs and identifies a TET2-GFI1 epigenetic axis that regulates HSC homeostasis.