Self-Assembled Generation of Multi-zonal Liver Organoids from Human Pluripotent Stem Cells
Hasan Al Reza, Connie Santangelo, Kentaro Iwasawa, Abid Al Reza, Sachiko Sekiya, Kathryn Glaser, Alexander J. Bondoc, Jonathan Merola, Takanori Takebe
This study develops self-assembled multi-zonal liver organoids from human pluripotent stem cells, revealing zonal-specific functions and epigenetic mechanisms that mimic human liver architecture.
Nature · Apr 16, 2025Peer-reviewedBioengineering