Takanori Takebe

Human lymphatic organoids reconstruct convergent developmental routes to functional lymphatic vessels

This study generates human lymphatic organoids from pluripotent stem cells using two mesodermal routes, showing they form functional vascular networks and support immune interactions.

An iPSC-based experimental framework for investigating phenotypic variation associated with Jomon ancestry in the present-day Japanese population

The paper develops a hiPSC-based framework to study ancestry-related phenotypic variation in the Japanese population, finding no hepatic triglyceride differences despite genetic associations.

OddSNP: a predictive framework for optimizing multiplexed single-cell RNA-seq experiments

OddSNP predicts the success of multiplexed single-cell RNA-seq experiments using SNP-IC and cpSNP-IC metrics to optimize sequencing depth and donor complexity.

Oncogenic Role of Aberrant EZH2 in Hepatoblastoma

This study identifies EZH2 as an oncogenic driver in hepatoblastoma, showing its role in promoting tumor progression through epigenetic silencing and noncanonical signaling, and highlights its potential as a therapeutic target.

Enhanced Piezoelectric Performance of PVDF-TrFE Nanofibers through Annealing for Tissue Engineering Applications

This study enhances the piezoelectric properties of PVDF-TrFE nanofibers through annealing, showing improved mechanical and biological responses for tissue engineering.

Self-Organization of Sinusoidal Vessels in Pluripotent Stem Cell-derived Human Liver Bud Organoids

This study develops a method to generate human liver bud organoids with functional sinusoidal vessels, demonstrating their potential for coagulation disorder therapies.

Primitive Hepatoblasts Driving Early Liver Development

The paper identifies and characterizes a new population of early hepatoblasts in mouse and human liver development, showing their role in liver bud formation and their decline in later stages.

Engineering Large-Scale and Innervated Functional Human Gut for Transplantation

This paper introduces a confined culture system to generate innervated human gut organoids that mature faster and support transplantation, enhancing engraftment and function.

Self-Assembled Generation of Multi-zonal Liver Organoids from Human Pluripotent Stem Cells

This study develops self-assembled multi-zonal liver organoids from human pluripotent stem cells, revealing zonal-specific functions and epigenetic mechanisms that mimic human liver architecture.

Inter-cellular mRNA Transfer Alters Human Pluripotent Stem Cell State

The paper shows that inter-species mRNA transfer from mouse embryonic stem cells to human pluripotent stem cells reprograms them to a naive-like state through specific transcription factors.

Matrix stiffness modulated release of spheroid-derived extracellular vesicles and discovery of Piezo1 cargo

This study shows that matrix stiffness modulates EV release and cargo from cancer spheroids, with stiff matrices promoting tumorigenic and metastatic profiles in EVs.

Fetal Liver-like Organoids Recapitulate Blood-Liver Niche Development and Multipotent Hematopoiesis from Human Pluripotent Stem Cells

Eicosatetraynoic Acid Regulates Pro-Fibrotic Pathways in an Induced Pluripotent Stem Cell Derived Macrophage:Human Intestinal Organoid Model of Crohns Disease

The paper tests eicosatetraynoic acid (ETYA) in a human intestinal organoid model to suppress pro-fibrotic pathways in macrophages associated with Crohn's Disease.

Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids

This study develops a human pluripotent stem cell-derived organoid system to investigate vascular, mesenchymal, and epithelial co-development in lung and intestinal organoids, revealing organ-specific endothelial and mesenchymal features.

Correction of a Factor VIII genomic inversion with designer-recombinases

This study corrects a 140 kb genomic inversion in the F8 gene using a designer recombinase system, restoring Factor VIII mRNA expression in patient-derived cells.

Single cell transcriptomics reveals a signaling roadmap coordinating endoderm and mesoderm lineage diversification during foregut organogenesis

The paper uses single-cell transcriptomics to map endoderm-mesoderm interactions during foregut organogenesis and validates signaling pathways in mice, then generates mesoderm subtypes from human pluripotent stem cells.