Kentaro Iwasawa

This study generates human lymphatic organoids from pluripotent stem cells using two mesodermal routes, showing they form functional vascular networks and support immune interactions.

This study develops a method to generate human liver bud organoids with functional sinusoidal vessels, demonstrating their potential for coagulation disorder therapies.

The paper identifies and characterizes a new population of early hepatoblasts in mouse and human liver development, showing their role in liver bud formation and their decline in later stages.

This study develops self-assembled multi-zonal liver organoids from human pluripotent stem cells, revealing zonal-specific functions and epigenetic mechanisms that mimic human liver architecture.

The paper tests eicosatetraynoic acid (ETYA) in a human intestinal organoid model to suppress pro-fibrotic pathways in macrophages associated with Crohn's Disease.

This study develops a human pluripotent stem cell-derived organoid system to investigate vascular, mesenchymal, and epithelial co-development in lung and intestinal organoids, revealing organ-specific endothelial and mesenchymal features.

This study corrects a 140 kb genomic inversion in the F8 gene using a designer recombinase system, restoring Factor VIII mRNA expression in patient-derived cells.

The paper uses single-cell transcriptomics to map endoderm-mesoderm interactions during foregut organogenesis and validates signaling pathways in mice, then generates mesoderm subtypes from human pluripotent stem cells.