p63 and PITX1 sustain a pre-invasive malignant keratinocyte population in squamous cell carcinoma precursors
Ramon Staeger, Aizhan Tastanova, Adhideb Ghosh, Paul Gueguen, Isabel Kolm, Egle Ramelyte, Evelyn Lattmann, Veronika Haunerdinger, Tugay Karakaya, Marta Slaufova, Michela Di Filippo, Hans‐Dietmar Beer, Mitchell Paul Levesque, Reinhard Dummer
The paper identifies a pre-invasive malignant keratinocyte population in actinic keratosis, characterized by p63 and PITX1 regulation, and distinguishes early oncogenic programs from invasion effectors in squamous cell carcinoma.
bioRxiv · May 24, 2026 · PreprintCancer Biology