Author

Isabel Kolm

Luzerner KantonsspitalORCID 0000-0002-6550-9057Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Hans‐Dietmar BeeriD· 2 shared Marta SlaufovaiD· 2 shared Michela Di FilippoiD· 2 shared Mitchell Paul LevesqueiD· 2 shared Tugay KarakayaiD· 2 shared Adhideb GhoshiD· 1 shared Aizhan TastanovaiD· 1 shared Egle RamelyteiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

Hans‐Dietmar BeerORCID

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2 papers

Recent·Most cited

NLRP1 inflammasome activation in skin equivalents revealsmechanistic insights into the roles of keratinocytes in psoriasis

Michela Di Filippo, Tugay Karakaya, Marta Slaufova, Phil Fang Cheng, Paulina Hennig, Petra Boukamp, Steve Pascolo, Julia‐Tatjana Maul, Isabel Kolm, Mitchell Paul Levesque, Thomas Kuendig, Hans‐Dietmar Beer

This study activates the NLRP1 inflammasome in skin equivalents to reveal a novel signaling axis involving IL-1 and IL-36γ in psoriasis.

Cell Death and Disease · May 29, 2026Peer-reviewedImmunology

p63 and PITX1 sustain a pre-invasive malignant keratinocyte population in squamous cell carcinoma precursors

Ramon Staeger, Aizhan Tastanova, Adhideb Ghosh, Paul Gueguen, Isabel Kolm, Egle Ramelyte, Evelyn Lattmann, Veronika Haunerdinger, Tugay Karakaya, Marta Slaufova, Michela Di Filippo, Hans‐Dietmar Beer, Mitchell Paul Levesque, Reinhard Dummer

The paper identifies a pre-invasive malignant keratinocyte population in actinic keratosis, characterized by p63 and PITX1 regulation, and distinguishes early oncogenic programs from invasion effectors in squamous cell carcinoma.

bioRxiv · May 24, 2026 · PreprintCancer Biology