Jingyi Jessica Li

The paper develops a method to profile spliceosome-bound RNA at nucleotide resolution in yeast, revealing non-canonical splicing events and substrate features influencing catalytic efficiency.

scImpute is a statistical method that imputes dropout values in scRNA-seq data, improving clustering, differential expression analysis, and gene expression dynamics studies.

The paper decomposes translation rate into mRNA-dependent and independent components, showing their distinct sequence determinants and impacts on protein expression in S. cerevisiae.