Adam D Longhurst

The regulation of Protein Phosphatase 4 by FBXO42 is required for cancer cell survival.

This study identifies FBXO42's role in regulating PPP4C and p53 signaling, showing its importance in cancer cell survival through genetic and proteomic analyses.

The PRC2.1 Subcomplex Opposes G1 Progression through Regulation of CCND1 and CCND2

The paper identifies PRC2.1's role in opposing G1 progression by regulating CCND1 and CCND2, showing its importance in cell proliferation across multiple cancer types.

A non-Dicer RNase III and four other novel factors required for RNAi-mediated transposon suppression in the human pathogenic yeast C. neoformans

The paper identifies five novel genes required for RNAi-mediated transposon suppression in C. neoformans, revealing a non-Dicer RNase III and nucleolar factors involved in endo-siRNA biogenesis.

Spliceosome profiling visualizes the operations of a dynamic RNP in vivo at nucleotide resolution

The paper develops a method to profile spliceosome-bound RNA at nucleotide resolution in yeast, revealing non-canonical splicing events and substrate features influencing catalytic efficiency.